We are currently enrolling patients that have type 2 diabetes and are also taking a DPP4-inhibitor which are inclusive of the medications: Januvia, Tradjenta, Nesina or Onglyza. If you are taking any of these medications then you could eligible for our trial and we would love to talk with you more. Fill out THIS FORM and we will be in contact with you about the opportunities.
As you could imagine by the name of the medication, if you have type 2 diabetes and are taking DPP4-inhibitors, then the DPP4 is being blocked. DPP4 stands for dipeptidyl peptidase-4 and by inhibiting this, you are downregulating the inhibition of GLP-1. This can get confusing quickly, but stick with us! GLP-1 lowers your blood glucose by secreting insulin so we want to have MORE GLP-1 around! By inhibiting the downregulation of this enzyme, we are able to keep more insulin around, which in turn helps to lower your blood glucose levels. This was a new approach to therapy in 2010 and has seen wonderful benefits for the patient including, but not limited to, the reduction of side effects.
Based on the way that the drug is metabolized, there are minimal drug-drug interactions, and have been shown in clinical trials to lower your A1C 0.6-0.9%. When comparing the amount of low blood glucose episodes with placeo, DPP4-inhibitors were shown to be about the same meaning that you shouldn’t experience any “bottoming-out of your sugars” for the most part with this medication. Episodes of hypoglycemia are common in other diabetic medications, so this is a preferred drug for many providers.
The most common side effects of patients with type 2 diabetes and DPP4-inhibitors are upper respiratory tract infections, allergic reactions, headaches, angioedema, and will need dose adjustments for those patients with kidney disease. If you experience any side effects from this medication, let your physician know and they will help you to find a therapy that is best for you.
Let us know if you have any questions about these medications, and if you think that you might be a candidate for this trial. Questions about trial involvement? See THIS LINK and fill out an INQUIRY form so that we can better serve you and get in contact with you personally.