Current Trials

Greensboro Clinical Studies

Meningitis Vaccine Trial

Meningitis is more common in teenagers and young children. The best option to help prevent this is the use of a vaccine against meningitis. This study is looking at how safe a potential new meningitis vaccine is and whether it may act as a booster in people who have already received a vaccine against 4 of the most common types of meningococcal germs that cause meningitis. The study will compare the investigational vaccine with an approved MenACWY vaccine called Menveo. You may be eligible to participate in this study if you meet the following criteria:

  • Are healthy
  • Are 15-25 years of age
  • Received 1 dose of a meningitis vaccine 4-6 years ago.

Participants will be in the study up to 12 months, receive free investigational vaccines and will receive reimbursement to participate.

Ankylosing Spondylitis (Inflammatory Back Pain)

Do you suffer with chronic low back pain and been diagnosed with Ankylosing Spondylitis or Spondyloarthritis as the cause? You may be eligible to participate in this 52 week trial if you have chronic low back pain that is caused by an inflammatory arthritis called Ankylosing Spondylitis. You may also have additional swollen and tender joints associated with this condition and this medication is being studied to determine it’s effectiveness and safety. Qualified participants must meet the following criteria:

  • Have chronic low back pain and stiffness due to a condition called Ankylosing Spondylitis or Spondyloarthritis with or without other joint involvement
  • At least 18 years of age
  • Must meet other inclusion and exclusion criteria

Qualified participants will receive study medication and care for Ankylosing Spondylitis or Spondyloarthritis at no cost and may be compensated to participate.

Colorectal Cancer Screen

Have you been advised to have a colonoscopy as part of your general health and well being as a screening tool for cancer? You may be eligible to participate if

  • You are at least 40 years of age or older
  • Standard of care colonoscopy is scheduled
  • Meet other inclusion and exclusion criteria

Patients will receive healthcare related to colon screening. Participation is free and compensation for qualified participants is available.

Continuous Glucose Monitoring Trial in Type 2 Diabetes Mellitus

Do you have Type 2 Diabetes Mellitus that is not under good control and currently performing fingerstick blood sugars to monitor it? We are currently conducting a clinical trial evaluating a Continuous Glucose Monitoring (CGM) system and it’s impact on your ability to control your blood sugars better. You may be eligible to participate in this study if you meet the following qualifications:

  • A1C is > 7.5%
  • Currently on at least one oral medication for diabetes
  • Not taking insulin
  • Meet other inclusion and exclusion criteria

Compensation for participation is provided

Crohn’s Disease

This is a 12-month study for patients with moderate to severe active CD. Qualified participants will receive study medication or placebo and care related to CD. Compensation for eligible patients is provided.

  • Between the ages of 18 and 80
  • Have a diagnosis of CD or fistulizing CD on lab report
  • Meet medication criteria and other inclusion/exclusion criteria

Diabetic Kidney Disease Trial

This study is for patients who have diabetes and chronic kidney disease.

  • Must be > 18 years old
  • Meet laboratory requirements
  • Not on dialysis
  • Meet other inclusion and exclusion criteria

This is a blinded study. Compensation for participation is provided.

Gastroesophageal Reflux Disease (GERD) Trial

Do you currently suffer from Gastroesophageal Reflux Disease (GERD) or Indigestion? You may be eligible to participate in this 10 week clinical trial if you meet the following requirements:

  • 18 years old or older
  • Suffer from symptoms of heartburn
  • Meet other inclusion and exclusion criteria

Participants will receive free study medication and care for GERD. Qualified participants may also receive reimbursement for participating in the study.

High Blood Pressure

Volunteer for this exciting study for high blood pressure! You may be able to participate if you meet the following criteria:

  • 18 years old or older
  • Currently have poorly controlled high blood pressure
  • On 2 or more medications for high blood pressure
  • Meet other inclusion/exclusion criteria

Participants will receive study medication, labs and medical care at no cost.

May receive compensation for completed study visits.

High Triglycerides-cholesterol

This 36 week study is for patients with severe hypertriglyceridemia (high triglycerides). Qualified patients will receive study medications at no cost. Compensation for eligible patients is provided.

  • Study candidates must have severely elevated triglyceride levels
  • Study candidates may be on fish oil or statins
  • Must meet other inclusion and exclusion criteria

Qualified patient will receive study medication or placebo and care related to high triglyceridemia. This study is being conducted at our Greensboro location.

Low Testosterone and Cardiovascular Disease

Have you been diagnosed with low testosterone? This is a long-term study to evaluate a topical medication for men with low testosterone between ages 45-80. Patients must:

  • Experienced a cardiovascular event such as a heart attack or stroke or have a blocked artery.
  • Meet laboratory testosterone levels.
  • Meet other inclusion and exclusion criteria.

Qualified participants will receive study medication or placebo and care related to low testosterone. Compensation for eligible patients is provided. This study is being conducted in both the Raleigh and Greensboro.

Oral Insulin in Type 2 Diabetes Mellitus

Do you have Type 2 Diabetes Mellitus and have difficulty controlling your blood sugars?

You may be eligible to participate in this study if you meet the following qualifications:

  • Have Type 2 Diabetes Mellitus AND have elevated blood sugars despite treatment with Metformin alone or with Metformin an up to 2 additional diabetes medications
  • Have not been on insulin for at least the past 6 months
  • Meet other inclusion and exclusion criteria

Qualified participants will receive care for their diabetes at no cost, study medication at no case, and may be paid to participate.

Rheumatoid Arthritis

Do you have Rheumatoid Arthritis that is poorly controlled and still have joint tenderness and swelling? You may be eligible to participate if:

  • You have moderate to severe Rheumatoid Arthritis
  • Continue to have swollen and tender joints
  • Must meet other inclusion and exclusion criteria

Qualified patients will receive study medication and care for Rheumatoid Arthritis at no cost and also may be compensated to participate.

Systemic Lupus Erythematosus (SLE)

A 52 week study for patients with moderate to severe Lupus who continue to have symptoms despite treatment. You may be eligible to participate if you meet the following criteria:

  • 18 years old or older
  • Diagnosed with Active Lupus for at least 24 weeks
  • Currently having breakthrough symptoms of Lupus despite treatment
  • Meet other inclusion/exclusion criteria

Study-related medications, labs and care provided at no cost.

May be compensated for completed study visits.

Raleigh Clinical Studies

Low Testosterone (Hypogonadism) and Cardiovascular Disease

Have you been diagnosed with low testosterone? This is a long-term study to evaluate a topical medication for men with low testosterone between ages 45-80. Patients must:

  • Experienced a cardiovascular event such as a heart attack or stroke or have a blocked artery.
  • Meet laboratory testosterone levels.
  • Meet other inclusion and exclusion criteria.

Qualified participants will receive study medication or placebo and care related to low testosterone. Compensation for eligible patients is provided. This study is being conducted in both the Raleigh and Greensboro.

Type 2 Diabetes Mellitus

Do you have Type 2 Diabetes Mellitus and have difficulty controlling your blood sugars?

You may be eligible to participate in this study if you meet the following qualifications:

  • Have Type 2 Diabetes Mellitus AND have elevated blood sugars despite treatment diabetes medications
  • Have never taken insulin
  • Meet other inclusion and exclusion criteria

Qualified participants will receive care for their diabetes at no cost, study medication at no cost, and may be paid to participate.

Cardiology (Greensboro) Clinical Studies

Cardiovascular Risk Reduction Trial

Do you have a history of a heart attack, stroke, and/or peripheral artery disease? You may be eligible for our research study to evaluate whether the study medication will reduce the risk of future events. You may be eligible if you meet the following criteria:

  • Be between the ages of 18 and 80
  • Must be receiving treatment to lower cholesterol
  • Have a history of a heart attack, stroke or peripheral arterial disease
  • Meet other inclusion and exclusion criteria

Participants will receive free cardiovascular risk evaluation, free study medication and may be compensated to participate.

Congestive Heart Failure

This study is for patients with congested heart failure who are:

  • Stable and have CHF
  • Laboratory values within study range
  • Age > 40 years old
  • Meet other inclusion and exclusion criteria

Qualified participants will receive study medication or placebo and care related to CHF. Compensation for eligible patients is provided.

Heart Attack Trial

Have you recently experienced a heart attack? We are currently conducting a research study in patients who have recently had a heart attack and are at risk for developing heart failure. You may be eligible for the study if you meet the following criteria:

  • Had a heart attack and it is within 14 days of your hospitalization
  • Have risk factors for developing heart failure
  • Meet other inclusion/exclusion criteria

Participation is free as is study medication and you may be compensated for your participation

Heart Failure with Reduced Ejection Fraction

This is a long-term study up to 3-5 years and is being conducted at the Greensboro facility. Qualified participants will receive study medication or placebo and care related to CHF. Compensation for eligible patients is provided. This trial is to determine the safety and efficacy of iron therapy using study medication relative to placebo in the treatment of participants in heart failure with a reduced heart function.

Patients must:

  • Have stable CHF
  • Left Ventricular Ejection Fraction < 35%
  • Meet laboratory values for the study
  • Meet other inclusion and exclusion criteria

Stable Angina

This is a 12-month study for patients with chronic stable angina. You may qualify for this study if you have

  • A history of stable angina
  • Documented coronary heart disease such as having an artery blockage or heart attack
  • Meets other inclusion and exclusion criteria

Patients will receive study medication or placebo as well as healthcare related to angina. Participation is free and compensation for qualified participants is available.

Urology (Greensboro) Clinical Studies

Prostate Cancer Trial

Have you been recently diagnosed with prostate cancer? You may be a candidate for an exciting clinical drug trial evaluating a new medication for the treatment of prostate cancer if you meet the following requirements:

  • 18 years old or older
  • Recently diagnosed with prostate cancer and at high risk for spread
  • Meet other inclusion/exclusion criteria

Participants who enroll in the trial will receive free medical care of prostate cancer, free study medication and compensation for participation.